Active — Not RecruitingNot Applicable

Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care

United States420 participantsStarted 2025-02-18

Plain-language summary

The goal of this project is to reduce unnecessary antibiotic use for children with ARTIs (Acute Respiratory Tract Infections) by implementing "outpatient antibiotic stewardship" across the Children's Hospital of Philadelphia (CHOP) Primary and Urgent Care Network to: 1. Reduce unnecessary antibiotic prescribing for the most common infections in children. 2. Reduce unnecessary a) broad-spectrum and b) longer-course antibiotic therapy for ear infections, Strep throat, sinus infections, and pneumonia.

Who can participate

Age range

6 Months – 12 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion * All children ages 6 months to 12 years seen at CHOP primary care network and CHOP Urgent Care with ARTI diagnoses (viral diagnoses or AOM, CAP, sinusitis, strep pharyngitis) Exclusion * Severe immunocompromised status OR tracheostomy dependence * Children with other bacterial infection diagnoses

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Antibiotic Prescribing Rates for Acute Respiratory Tract Infections (ARTIs)

Timeframe: From start of implementation ramp up period to end of year 2 implementation

Change in overall optimal antibiotic prescribing rates for all bacterial ARTI encounters

Timeframe: From start of implementation ramp up period to end of year 2 implementation

Broad- versus Narrow-Spectrum Antibiotic Prescribing

Timeframe: From start of implementation ramp up period to end of year 2 implementation

Shortest Effective Duration Antibiotic Prescribing

Timeframe: From start of implementation ramp up period to end of year 2 implementation

Trial details

NCT IDNCT07217002

SponsorChildren's Hospital of Philadelphia

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-05

View on ClinicalTrials.gov More Community Acquired Pneumonia (CAP) trials

Plain-language summary

Who can participate

Age range

6 Months – 12 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Antibiotic Prescribing Rates for Acute Respiratory Tract Infections (ARTIs)

Timeframe: From start of implementation ramp up period to end of year 2 implementation

Change in overall optimal antibiotic prescribing rates for all bacterial ARTI encounters

Timeframe: From start of implementation ramp up period to end of year 2 implementation

Broad- versus Narrow-Spectrum Antibiotic Prescribing

Timeframe: From start of implementation ramp up period to end of year 2 implementation

Shortest Effective Duration Antibiotic Prescribing

Timeframe: From start of implementation ramp up period to end of year 2 implementation