Not Yet RecruitingNot Applicable

Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss

United States100 participantsStarted 2026-06

Plain-language summary

Reading performance in patients with Central Vision Loss will be measured with and without missing text being remapped to different parts of the visual field in a variety of different reading tasks.

Who can participate

Age range

16 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Dense bilateral scotomas of at least 2 deg diameter in each eye covering the fovea * Bivariate contour ellipse area (BCEA) of less than 10\^2 is obtained in a simple fixation task Exclusion Criteria: * Neovascular AMD * Any history of visual disorders other than that causing the central vision loss.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Sentence reading speed

Timeframe: Measured on day 35, end of the Personalised Remapping Training in the 33 participants in the Perceptual Learning arm.

Sentence reading accuracy

Timeframe: Measured on day 35, end of the Personalised Remapping Training in the 33 participants in the Perceptual Learning arm.

Word reading speed: RSVP

Timeframe: Measured on day 21, end of the RSVP Remapping intervention in the 33 participants in the Rapid Serial Visual Presentation arm.

Word recognition accuracy: RSVP

Timeframe: Measured on day 21, end of the RSVP Remapping intervention in the 33 participants in the Rapid Serial Visual Presentation arm.

Word reading speed: Reading in The Wild

Timeframe: Measured on day 21, end of the Reading Text in The Wild with Remapping intervention in the 33 participants in the Reading in The Wild arm.

Word recognition accuracy: Reading in the wild

Timeframe: Measured on day 21, end of the Reading Text in The Wild with Remapping intervention in the 33 participants in the Reading in The Wild arm.

Trial details

NCT IDNCT07216924

SponsorUniversity of Minnesota

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2031-05

Contact for this trial

Stephen A Engel, Ph.D.

6126255571 engel@umn.edu

View on ClinicalTrials.gov More Macular Degeneration trials

Who can participate

Age range

16 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Sentence reading speed

Timeframe: Measured on day 35, end of the Personalised Remapping Training in the 33 participants in the Perceptual Learning arm.

Sentence reading accuracy

Timeframe: Measured on day 35, end of the Personalised Remapping Training in the 33 participants in the Perceptual Learning arm.

Word reading speed: RSVP

Timeframe: Measured on day 21, end of the RSVP Remapping intervention in the 33 participants in the Rapid Serial Visual Presentation arm.

Word recognition accuracy: RSVP

Timeframe: Measured on day 21, end of the RSVP Remapping intervention in the 33 participants in the Rapid Serial Visual Presentation arm.

Word reading speed: Reading in The Wild

Timeframe: Measured on day 21, end of the Reading Text in The Wild with Remapping intervention in the 33 participants in the Reading in The Wild arm.

Word recognition accuracy: Reading in the wild

Timeframe: Measured on day 21, end of the Reading Text in The Wild with Remapping intervention in the 33 participants in the Reading in The Wild arm.