RecruitingNot Applicable

Follicular Fluid microRNAs in Ovarian Aging and Reproduction

United States100 participantsStarted 2025-09-22

Plain-language summary

The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes. The goal is to identify noninvasive molecular markers that correlate with oocyte quality and reproductive potential, particularly in women of advanced maternal age.

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women undergoing IVF treatment due to male factor infertility or nonovarian causes. * Age groups: younger women \<31 years and older women \>38 years. * Regular menstrual cycles. * Willing and able to provide informed consent. Exclusion Criteria: * Minors (under 18 years) and women aged 32-37 years * Diagnosis of polycystic ovarian syndrome (PCOS). * History of recurrent pregnancy loss. * Presence of endometriosis. * Diagnosis of ovarian insufficiency. * Metabolic disorders (e.g., diabetes). * History of ovarian surgery or chemotherapy. * Any condition that might impact follicular fluid quality or IVF outcomes.

What they're measuring

Identify exosomal miRNAs using RNA sequencing

Timeframe: 1 year

Validate and assess miRNA for IVF

Timeframe: 1 year

Determine molecular pathways regulated by age

Timeframe: 1 year

Trial details

NCT IDNCT07214246

SponsorUniversity of Central Florida

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-09

Contact for this trial

Amoy Fraser, PhD, CCRP, PMP

4072668742 Amoy.Fraser@ucf.edu

View on ClinicalTrials.gov More Ovarian Aging trials