CompletedNot Applicable

Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers

Turkey (Türkiye)33 participantsStarted 2023-12-10

Plain-language summary

This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * no periodontal treatment within the previous 6 months; * no use of antibiotics within the previous 3 months; * no systemic disease and alcohol drinkers, or drug users; * no use of anti-inflammatory drugs within the past 3 months; * no pregnancy; * no use of hormonal contraceptives; and * current smokers with a history of smoking ≥10 cigarettes per day for at least one year. Exclusion Criteria: * Patients with \<20 teeth, grade III tooth mobility, partial dentures, or fixed prostheses were excluded. Additionally, those with dental implants or peri-implant diseases were also excluded.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Probing Pocket Dept (PPD)

Timeframe: Through study completion, an average of 3 months.

Periodontal Epithelial Surface Area (PESA)

Timeframe: Through study completion, an average of 3 months.

Periodontal Inflamed Surface Area (PISA)

Timeframe: Through study completion, an average of 3 months.

Salivary Malondialdehyde Levels

Timeframe: Through study completion, an average of 3 months.

Salivary 8-hydroxy-2'-deoxyguanosine Levels

Timeframe: Through study completion, an average of 3 months.

PPD ≥4 mm, site-specific PPD (ssPPD)

Timeframe: Through study completion, an average of 3 months.

PPD ≥4 mm, site spesific CAL (ssCAL)

Timeframe: Through study completion, an average of 3 months.

Trial details

NCT IDNCT07213752

SponsorSelcuk University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-01-21

View on ClinicalTrials.gov More Periodontitis trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Probing Pocket Dept (PPD)

Timeframe: Through study completion, an average of 3 months.

Periodontal Epithelial Surface Area (PESA)

Timeframe: Through study completion, an average of 3 months.

Periodontal Inflamed Surface Area (PISA)

Timeframe: Through study completion, an average of 3 months.

Salivary Malondialdehyde Levels

Timeframe: Through study completion, an average of 3 months.

Salivary 8-hydroxy-2'-deoxyguanosine Levels

Timeframe: Through study completion, an average of 3 months.

PPD ≥4 mm, site-specific PPD (ssPPD)

Timeframe: Through study completion, an average of 3 months.

PPD ≥4 mm, site spesific CAL (ssCAL)

Timeframe: Through study completion, an average of 3 months.