Low-Flow Desflurane Anesthesia and Its Effects on BIS and Postoperative Cognitive Functions (NCT07212543) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Low-Flow Desflurane Anesthesia and Its Effects on BIS and Postoperative Cognitive Functions
Turkey (Türkiye)72 participantsStarted 2025-05-15
Plain-language summary
This study investigates the effects of low-flow desflurane anesthesia in adult patients undergoing major abdominal surgery. The researchers will examine whether different low-flow strategies:
Cause differences in the Bispectral Index (BIS), which measures brain activity during anesthesia, Affect postoperative cognitive functions such as memory and attention.
Participants will:
Receive desflurane anesthesia during surgery, Have anesthesia delivered at different low-flow rates, Have their BIS values monitored throughout the operation, Complete tests after surgery to evaluate their cognitive functions.
This research will help determine the safety of different low-flow strategies and their impact on patients' cognitive recovery after surgery.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Patients aged 18-75 years
ASA physical status I-III
Scheduled for elective major abdominal surgery
Provided written informed consent
Normal preoperative neurocognitive function
Exclusion Criteria:
History of neurological or psychiatric disorders
History of cognitive impairment
Diagnosed hepatic or renal insufficiency
Presence of other systemic diseases contraindicating anesthesia
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from Baseline in Mini-Mental State Examination (MMSE) Score Postoperatively
Timeframe: From baseline (preoperative assessment, within 24 hours before surgery) to postoperative assessments at 24 hours and 7 days after surgery