Evaluation of Dalia Solution For Depressed Patient

Inclusion Criteria: * Age ≥ 18 years * Patient with a diagnosis of depressive episode, as defined by ICD-11, and with a PHQ-9 score ≥ 15 confirmed by a psychiatrist or general practitioner * Patient receiving a first antidepressant treatment (treatment-naïve) OR having had a modification of antidepressant treatment in the two weeks prior to inclusion * Patient equipped with a smartphone or a computer or a tablet with internet access * Patient affiliated to a health insurance scheme * Patient able to read and understand French * Patient having signed informed consent Exclusion Criteria: * Patient under non-cardioselective beta-blocker (carvedilol, labetalol, propranolol, pindolol) and beta-mimetic (salbutamol, terbutaline) * Patient with a pacemaker or with a known cardiac arrhythmia * Patient with major neurocognitive disorder (e.g., dementia) or psychotic disorders likely to compromise participation in the study * Patient hospitalized at the time of inclusion whose discharge is not planned within the next two weeks * Patient treated with esketamine * Patient with excessive consumption of psychoactive substances (alcohol or drugs), which may interfere with the course or follow-up of the study * Patient unable to wear the bracelet during the study due to dermatological conditions * Patient under guardianship, curatorship, or legal protection, or any other administrative or judicial measure depriving rights and freedom * Patient considered non-autonomous by the investigator …