Acquired Dyslexia Modeling and Treatment (NCT07209488) | Clinical Trial Compass
RecruitingNot Applicable
Acquired Dyslexia Modeling and Treatment
United States12 participantsStarted 2025-12-03
Plain-language summary
This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Fluent in English as a first language pre-stroke by self report.
* Normal or corrected-to-normal vision.
* Normal or aided hearing.
* Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan).
* Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III.
Exclusion Criteria:
* Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke.
* Severe apraxia of speech (determined by consensus judgment among speech-language pathologists).
* History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders.
* Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Woodcock Reading Mastery Test - III
Timeframe: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.
2
Test words and pseudowords
Timeframe: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.
Trial details
NCT IDNCT07209488
SponsorRutgers, The State University of New Jersey