Endocrine Dysfunction in Pediatric Wilson's Disease

Inclusion Criteria: * Children aged 3-18 years Confirmed diagnosis of Wilson's disease (based on clinical features, biochemical markers such as serum ceruloplasmin and 24-hour urinary copper) Both newly diagnosed and treated patients (chelation/zinc therapy) Informed consent from parents or guardians Exclusion Criteria: * Congenital or acquired endocrine disorders unrelated to WD (e.g., congenital hypothyroidism, pituitary tumors) Concurrent use of medications affecting hormonal function unless prescribed for WD (steroids, thyroid replacements, contraceptives) Chronic systemic illnesses that confound endocrine assessment (e.g., malignancy, chronic renal failure)