CompletedNot Applicable

AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness

China394 participantsStarted 2021-09-01

Plain-language summary

This study is a proteomics-based diagnostic biomarker study conducted on the same patient cohort as the transcriptomic biomarker study (NCT065529754). Although both studies share the same clinical cohort and overarching diagnostic aim, they are registered separately because they employ distinct omics technologies, investigate different biomarker modalities, and yield independent outcome measures.

Who can participate

Age range14 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥14 years； * Body temperature \> 38°C(within the past 72 hours)； * Disease duration ≤ 14 days； * Provision of informed consent by patient or legal guardian. Exclusion Criteria: * Underlying diseases affecting immune function (e.g., advanced malignancy, autoimmune disease, immunodeficiency, use of immunosuppressants); * Pregnancy; * Mixed infections (including viral-bacterial co-infections, bacterial or viral-fungal co-infections, or autoimmune disease concomitant with bacterial infection); * indeterminate or negative microbiological testing ; * inability to provide informed consent

What they're measuring

Diagnostic Accuracy (AUROC) for differentiating bacterial vs viral infection

Timeframe: At hospital admission (retrospective review of cases from September 1, 2021 to October 31, 2024)

Trial details

NCT IDNCT07205575

SponsorQilu Hospital of Shandong University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-10-31

View on ClinicalTrials.gov More Acute Febrile Illness trials