CompletedNot Applicable

Inflammatory Response Under Spinal vs General Anesthesia in PCNL: NLR, RDW, LAR.

Turkey (Türkiye)90 participantsStarted 2025-09-22

Plain-language summary

This observational study compares the effects of spinal versus general anesthesia on the perioperative systemic inflammatory response in adults undergoing PCNL. Routine clinical laboratory values (NLR, RDW, LAR) obtained preoperatively and postoperatively will be recorded to evaluate between-group and within-group changes. No additional blood sampling will be performed beyond standard care.

Who can participate

Age range18 Years – 99 Years

SexALL

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Inclusion Criteria: Age ≥18 years ASA physical status I-III Scheduled for percutaneous nephrolithotomy (PCNL) Provided informed consent Exclusion Criteria: Active infection or sepsis Known malignancy Chronic inflammatory or autoimmune disease (e.g., rheumatoid arthritis, systemic lupus erythematosus) Current immunosuppressive therapy Pregnancy

What they're measuring

Change in Neutrophil-to-Lymphocyte Ratio (ΔNLR)

Timeframe: Baseline (≤6 hours preoperative) and 24 hours postoperatively

Trial details

NCT IDNCT07205224

SponsorSevim Şenol Karataş

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-10-22

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