CompletedNot Applicable

Fiber-Enriched Enteral Nutrition and Opioid-Induced Constipation in the ICU

Turkey (Türkiye)80 participantsStarted 2024-12-20

Plain-language summary

Opioid use for sedation and analgesia is widespread among mechanically ventilated ICU patients, often leading to gastrointestinal dysfunction and opioid-induced constipation (OIC). While enteral nutrition (EN) is routinely used in critical care, the role of fiber-enriched EN formulas in preventing OIC remains unclear. This prospective quasi-randomized study aims to evaluate whether fiber-containing EN products reduce the incidence and severity of OIC compared to fiber-free formulations in intubated ICU patients. The findings may contribute to optimizing nutritional strategies to mitigate constipation-related complications in this high-risk population.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All patients over the age of 18 who are initiated on enteral nutrition and are on mechanical ventilation will be included in the study. Exclusion Criteria: * Pediatric and pregnant patients * Life expectancy less than 24 hours * Gastrointestinal surgery within the last week * Intra-abdominal pressure \> 15 mmHg * Shock requiring high vasopressor support * Contraindication to enteral nutrition * Intubation \>48 hours

What they're measuring

the day of first defecation

Timeframe: 1-7 days

Trial details

NCT IDNCT07201428

SponsorSisli Hamidiye Etfal Training and Research Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-07-30

View on ClinicalTrials.gov More Constipation, Opioid-Induced trials