Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) (NCT07200739) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
Denmark440 participantsStarted 2026-06-01
Plain-language summary
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic. The main questions it aims to answer are:
Can the AI model accurately distinguish between patients who need referral to a memory clinic (those with dementia or Mild Cognitive Impairment) and patients who don't (those with normal cognition or memory problems from other causes like depression)? Which speech patterns and cognitive test features are most useful for making this distinction?
Researchers will compare speech recordings and cognitive test results from patients diagnosed with dementia or MCI to those from patients with normal cognition or non-neurodegenerative cognitive impairment to see if the AI model can reliably predict who needs specialist dementia care.
Participants will:
Complete standard cognitive tests at the memory clinic Perform structured speech tasks while being audio-recorded Receive their usual clinical evaluation and diagnosis from memory clinic specialists
The results of this study will help develop a tool that can assist doctors in making faster, more accurate decisions about which patients need specialist dementia evaluation, potentially leading to earlier diagnosis and better patient outcomes.
Who can participate
Age range
50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Model A (patient participants)
* Age \> 50 years
* Fluent in Danish
* Minimum of 7 years of schooling
* A diagnosis of either MCI or AD, given at the SUH memory clinic within 6 months before enrollment
Model A (cognitively healthy controls)
* Age \> 50 years
* Fluent in Danish
* Minimum of 7 years of schooling
Model B:
* Age \> 50 years
* Fluent in Danish
* Minimum of 7 years of schooling
Exclusion Criteria:
Model A:
Patients:
* Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis)
* MMSE score \< 16
* Concomitant diagnoses which are expected to influence cognitive impairment (eg. depression)
* Patients unable to give consent
* Patients with alcohol consumption \>21 standard alcohol units per week
* Any history of speech or language impairment predating the current condition
Cognitively healthy controls:
* Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis)
* MMSE \< 26 and ACE \< 90
* Clinical, laboratory, or neuroradiological findings that could affect cognitive functions
* Known diseases which are expected to impair cognitive functions
* Any history of speech or language impairment predating the current condition
* Patients with alcohol consumption \>21 standard alcohol units per week.
Model B:
* Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis)
* MMSE score \< 1…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Model A: Primary measure is the AUC-ROC of the model in distinguishing between MCI and AD as well as between MCI and cognitively healthy control participants.