Not Yet RecruitingNot Applicable

Clinical Evaluation of Local Calcitriol Delivery on Maxillary Canine Retraction

22 participantsStarted 2025-11-01

Plain-language summary

This study will evaluate the effect of locally applied Calcitriol on dental and skeletal changes during upper canine retraction. It is a split-mouth randomized clinical trial, where Calcitriol will be locally applied on one side of the maxilla, and the other side will serve as control.

Who can participate

Age range13 Years – 35 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Presence of class I malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.
✓. Presence of class II malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.
✓. Age range between 13 and 35 years to include both adolescent and adult patients suitable for orthodontic treatment.
✓. Presence of permanent dentition.
✓. Good oral hygiene.

Exclusion criteria

✕. History of chronic systemic disease.
✕. Presence of active gingival or periodontal disease.
✕. Known allergy or hypersensitivity to vitamin D.
✕. Pregnancy or lactation.
✕. History of previous orthodontic treatment.
✕. Presence of craniofacial anomalies affecting bone physiology.

What they're measuring

Amount of maxillary canine retraction (mm) assessed on CBCT scans

Timeframe: T0: immediately before maxillary canine retraction. T1: after completion of canine retraction (approximately 4 months - 6 months)

Trial details

NCT IDNCT07200349

SponsorAl-Azhar University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09

View on ClinicalTrials.gov More Maxillary Canine Retraction trials