Clinical Evaluation of Local Calcitriol Delivery on Maxillary Canine Retraction (NCT07200349) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Clinical Evaluation of Local Calcitriol Delivery on Maxillary Canine Retraction
22 participantsStarted 2025-11-01
Plain-language summary
This study will evaluate the effect of locally applied Calcitriol on dental and skeletal changes during upper canine retraction. It is a split-mouth randomized clinical trial, where Calcitriol will be locally applied on one side of the maxilla, and the other side will serve as control.
Who can participate
Age range
13 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Presence of class I malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.
. Presence of class II malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.
. Age range between 13 and 35 years to include both adolescent and adult patients suitable for orthodontic treatment.
. Presence of permanent dentition.
. Good oral hygiene.
Exclusion criteria
. History of chronic systemic disease.
. Presence of active gingival or periodontal disease.
. Known allergy or hypersensitivity to vitamin D.
. Pregnancy or lactation.
. History of previous orthodontic treatment.
. Presence of craniofacial anomalies affecting bone physiology.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Amount of maxillary canine retraction (mm) assessed on CBCT scans
Timeframe: T0: immediately before maxillary canine retraction. T1: after completion of canine retraction (approximately 4 months - 6 months)