Not Yet RecruitingNot Applicable

Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy

60 participantsStarted 2025-10-20

Plain-language summary

To compare the intraoperative effects of Dexmedetomidine and Magnesium Sulfate infusion on intracranial pressure and cerebral perfusion pressure in adult patients undergoing craniotomy

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-65 years * Elective craniotomy for supratentorial pathology * No contraindication to lumbar drain insertion * Baseline mental status is stable, allowing for a reliable postoperative neurological evaluation can be done * ASA physical status I-III Exclusion Criteria: * Coagulopathy or current anticoagulation * Severe renal or hepatic dysfunction * Known allergy to study medications * traumatic brain injury

What they're measuring

Change in ICP and CPP in craniotomy

Timeframe: o Pre-loading o After loading o Once the patient is in position (other than baseline) o After 30 min of incision (or every 30-60 min till skin closure)

Trial details

NCT IDNCT07199595

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-10-01

Contact for this trial

Hassan mostafa, Assistant lecturer

01060264751 hassan.mostafa9444@gmail.com

View on ClinicalTrials.gov More Craniotomy Surgery trials