CompletedNot Applicable

Clinical Application of the Effect of Respiratory Muscles Electrical Stimulation on Weaning in Patients With Difficult Weaning of the Mechanical Ventilation

China300 participantsStarted 2025-09-29

Plain-language summary

This trial evaluates whether transcutaneous diaphragmatic/phrenic nerve stimulation (TEDS), abdominal functional electrical stimulation (abFES), or their combination, accelerates and improves the quality of weaning from prolonged invasive mechanical ventilation (IMV), compared with standardized ICU care with sham stimulation.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Invasive mechanical ventilation ≥21 days for PMV(at least 6 hours per day); expected ≥48 h Invasive mechanical ventilation. Eligible for standardized weaning protocol and SBT assessment. Informed consent by participant or legally authorized representative. Exclusion Criteria: * Non-screenable/unstable arrhythmia or hemodynamics; refractory hypoxemia/hypercapnia. Pacemaker/ICD not shieldable; seizure disorder uncontrolled. Recent abdominal surgery or skin breakdown at electrode sites; BMI\>35; pregnancy. Prone positioning; continuous deep neuromuscular blockade; investigator deems unsuitable.

What they're measuring

Time to Successful Weaning (days)

Timeframe: From randomization up to Day 28

Trial details

NCT IDNCT07199036

SponsorCapital Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-01

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