Not Yet RecruitingNot Applicable

Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection

United States546 participantsStarted 2026-02

Plain-language summary

The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. ≥ 18 years of age
✓. Ability to provide informed consent
✓. Willing and able to complete one electronic survey
✓. Presenting for colonoscopy for any indication
✓. Ability to understand the requirements of the study and agree to abide by the study restrictions and to return for the required assessments.
✓. Size 20-50 mm as documented with photo containing open snare of known size as comparison.
✓. Histology without high grade dysplasia:
✓. Conventional Adenoma: adenoma with or without villous components

Exclusion criteria

✕. Patients with confirmed diagnosis of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease.
✕. Patients with a known or suspected diagnosis of any of the following polyposis or non-polyposis syndromes with known genetic mutations:
✕. Patients who have high grade dysplasia found in any polyp ≥ 20 mm removed at the index colonoscopy
✕. Patients who have any colorectal cancer by histologic diagnosis at index procedure
✕. Patients needing a colonoscopy 6 months or sooner for any indication following the index procedure including burden of synchronous disease, inadequate prep to assess for synchronous disease, inadequate prep that precludes resection of index large polyp, or other reason limiting ability to complete full examination of colon at time of resection.
✕. ASA ≥ 4 or documented coagulopathy or severe thrombocytopenia (INR ≥ 2 or platelets ≤ 20).
✕. Patients who have more than three ≥ 20mm polyps removed during the index colonoscopy
✕. Patients with significant acute or chronic medical, neurologic, or illness that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability to complete the study, and/or compromise the objectives of the study.

What they're measuring

Rate of recurrence

Timeframe: 1 day

Trial details

NCT IDNCT07198945

SponsorIndiana University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-08

Contact for this trial

Rachel E Lahr, BA

317-278-2328 rlahr@iu.edu

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