Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft T… (NCT07198126) | Clinical Trial Compass
By InvitationNot Applicable
Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft Transplantation
Pakistan130 participantsStarted 2025-08-30
Plain-language summary
Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted vision (astigmatism). The condition is more frequent in people exposed to sunlight, dust, and dry environments.
The standard treatment for symptomatic pterygium is surgical removal. However, simple removal has a high chance of recurrence. To reduce this risk, surgeons commonly use a technique called conjunctival autograft transplantation, where a small piece of the patient's own conjunctiva is placed over the area after excision. This method not only lowers the recurrence rate but may also improve vision by reducing corneal irregularities.
This study is designed to measure the changes in corneal curvature (keratometric readings) before and after pterygium excision with conjunctival autograft transplantation. By comparing preoperative and postoperative measurements, the study aims to determine how much this surgery improves corneal shape and reduces astigmatism.
The hypothesis is that pterygium excision with conjunctival autograft transplantation will lead to a significant improvement in keratometric readings and reduce irregular astigmatism, thereby improving visual quality.
This research will provide local evidence of the effectiveness of this procedure and help guide treatment strategies for patients suffering from pterygium-related visual problems.
Who can participate
Age range
30 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults of either sex aged \>30 to 70 years.
* Phakic eyes.
* Primary pterygium, Grade II or Grade III (as per protocol grading).
* Presence of corneal astigmatism on pre-operative assessment.
* Scheduled for pterygium excision with conjunctival autograft transplantation at the study site.
* Able to provide written informed consent and to attend the 1-month postoperative assessment.
Exclusion Criteria:
* Pseudophakic or aphakic eyes.
* Recurrent pterygium.
* Prior keratoplasty or trabeculectomy in the study eye.
* Keratoconus or other corneal pathologies that can independently induce astigmatism.
* Lenticular astigmatism or significant lens pathology affecting refraction.
* Eyes planned for simple pterygium excision without conjunctival autograft.
* Any ocular condition or systemic illness judged likely to interfere with keratometric or refractive measurements, follow-up, or surgical safety.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is measuring changes in corneal curvature readings before and after pterygium removal with a conjunctival autograft — can you explain what those keratometric readings actually tell us about how the pterygium has been affecting my vision or astigmatism?
2Since this trial is 'enrolling by invitation,' does that mean I would need to be referred or selected by a specific surgeon or clinic, and how would I find out if I might be considered?
3The study is listed as Phase NA, which typically means it's observational or involves a standard surgical procedure rather than an experimental treatment — does that mean the surgery itself is already an established option for me, and the study is mainly tracking outcomes?
4How significant is my current corneal astigmatism, and would participating in this study — which tracks keratometric changes after surgery — give my care team more detailed information about my individual recovery compared to what's collected in routine follow-up care?
5If I choose not to take part in this study, would I still be able to have pterygium excision with conjunctival autograft as a standard treatment, and would my follow-up care be any different?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Keratometric Readings (K1 and K2)
Timeframe: Baseline (pre-operative) and 1 month post-operative.