2-HOBA Supplementation in People With Elevated Lipoprotein(a) (NCT07198009) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
2-HOBA Supplementation in People With Elevated Lipoprotein(a)
United States10 participantsStarted 2025-11-01
Plain-language summary
The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels.
The main questions it aims to answer are:
Does 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood?
Participants will:
Take 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers
Who can participate
Age range
18 Years – 69 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Males and females aged 18-69 years.
* Elevated Lp(a) levels ≥ 90 mg/dL.
* Able to provide informed consent and adhere to study schedules.
* Willing to follow a physician-recommended diet during the study.
Exclusion Criteria:
* Pregnant, planning pregnancy during the study period, or currently breastfeeding.
* Individuals with established cardiovascular disease
* Planning major changes in diet or exercise routines.
* Experienced \>20% weight change in the past 3 months.
* Diagnosed with malabsorption syndrome or chronic diarrhea.
* Abnormal liver, kidney, or thyroid function.
* Drug or alcohol abuse within the past 6 months, or significant mental/psychological impairment.
* Have known bleeding disorders (e.g., hemophilia).
* Planned surgery during the study period.
* Donated blood within the last 2 weeks or planning to donate during the study.
* Require regular blood transfusions.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in oxidized phospholipids (OxPL) on circulating lipoprotein(a)