Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma
Iran150 participantsStarted 2025-05-01
Plain-language summary
This study evaluates the effectiveness and safety of YAG laser peripheral iridotomy performed at two different locations (temporal and inferior) in patients with primary angle-closure glaucoma, a leading cause of blindness worldwide. Patients visiting the glaucoma clinic at Feiz Hospital who are candidates for peripheral iridotomy will participate. In each patient, one eye will receive a temporal iridotomy, and the other eye will receive an inferior iridotomy, with patients unaware of the location used in each eye. The study will measure outcomes such as laser power, intraocular pressure, visual symptoms, and complications over six months to determine which approach is more effective and safer.
Who can participate
Age range
24 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:Diagnosis of Primary Angle-Closure Glaucoma.
Adults (typically over 40 years old).
Ability to provide informed consent.
Narrow or closed anterior chamber angle (based on gonioscopy).
Intraocular pressure (IOP) controlled with medication but requiring surgery.
No previous iridotomy.
Exclusion Criteria:econdary glaucoma.
Active eye diseases (e.g., infection or inflammation).
Advanced cataracts or lens-related issues.
Severe visual impairment (e.g., less than 20/200 vision).
Uncontrolled systemic diseases (e.g., diabetes or cardiovascular disease).
Pregnancy or breastfeeding.
Previous eye surgery (except for minor procedures).
Inability to follow-up with scheduled visits.
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Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial is specifically testing YAG laser iridotomy for angle-closure glaucoma and its primary focus is measuring adverse events, what does that tell us about what is and isn't yet well understood about the safety of this procedure?
2The trial is listed as 'active but not recruiting,' which means new patients can't join — but could the results from this study influence my own treatment plan once they become available, and how soon might that be?
3Given that this trial is categorized as Phase NA, meaning it doesn't fit the standard drug trial phases, how does that affect how much we can know about the balance of risks and benefits of YAG laser iridotomy compared to other treatment options for my angle-closure glaucoma?
4Since the main thing being measured in this trial is adverse events, what are the known or suspected risks of YAG laser iridotomy that motivated researchers to study this, and how do those risks compare to not treating my angle-closure glaucoma?
5Are there standard treatments for angle-closure glaucoma — such as medications or other surgical options — that my care team would recommend I consider before or instead of a procedure like YAG laser iridotomy that is still being actively studied?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.