CompletedNot Applicable

Dietary Fiber and Probiotics in Advanced Colorectal Cancer

China80 participantsStarted 2022-05-01

Plain-language summary

This single-center, prospective, randomized controlled trial was conducted to evaluate the efficacy of a 12-week combined dietary fiber and probiotic supplementation on gut microbiota, immune function, nutritional status, and survival outcomes in malnourished patients with advanced colorectal cancer undergoing conventional therapy, compared to standard nutritional support alone.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pathologically confirmed diagnosis of stage II-IV colorectal cancer post-resection. * Receiving active adjuvant chemotherapy. * Documented moderate-to-severe malnutrition (PG-SGA score ≥ 4). * Ability to tolerate oral intake. * Voluntarily signed the informed consent form. Exclusion Criteria: * Presence of complete bowel obstruction. * Severe, uncontrolled organ dysfunction (cardiac, hepatic, renal). * Known allergy to any component of the nutritional supplements. * Concurrent participation in another interventional trial.