Active — Not RecruitingNot Applicable

Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection (TORPIDS-3)

United Kingdom326 participantsStarted 2024-01-09

Plain-language summary

Pleural infection is a severe and complicated disease which is associated with significant morbidity and mortality. People with pleural infection show diverse levels of neutrophil degranulation activity. The investigators examined the biological role of pleural fluid neutrophil extracellular traps in patients with pleural infection. TORPIDS-3 is an observational, International multicohort study.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Pleural fluid that was macroscopically purulent, OR
✓. Pleural fluid that was positive on culture for bacterial infection, OR
✓. Pleural fluid that demonstrated bacteria on Gram staining, OR
✓. Pleural fluid with pH ≤7.2 (measured in a blood gas analyser) or low glucose level (≤3mmol/L or ≤55mg/dL) in a patient with clinical evidence of infection, OR

Exclusion criteria

✕. Age less than 18 years, OR
✕. No pleural fluid available for analysis, OR
✕. Patient previous pneumonectomy on the side of pleural infection, OR
✕. Expected survival less than three months due to co-morbid disease, as judged by the recruiting physician

What they're measuring

Disease severity

Timeframe: Baseline

One-year mortality

Timeframe: Baseline

Trial details

NCT IDNCT07194915

SponsorUniversity of Oxford

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-08-31

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