CompletedNot Applicable

Effect of Locally Applied Simvastatin Gel on Dental Implant Stability and Marginal Bone Level

Iraq42 participantsStarted 2024-10-03

Plain-language summary

stability and marginal bone level. Forty-two patients received dental implants and were randomly assigned to two groups. In the test group, 1.2% simvastatin in 4% methylcellulose gel was applied around the implant, while in the control group, methylcellulose gel alone was used. Implant stability was measured using resonance frequency analysis at baseline, 8 weeks, and 16 weeks. Marginal bone level was assessed by cone-beam computed tomography (CBCT) at baseline and 16 weeks. The aim of the study was to investigate whether local application of simvastatin enhances osseointegration and reduces marginal bone loss compared to the control treatment.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Healthy patients ≥ 18 years of either gender.
✓. Having missing teeth in maxillary jaw maxillary jaw( premolar and molar area) at least 6 months after teeth extraction.
✓. Patients who had alveolar ridges of sufficient vertical and horizontal dimensions and were considered surgically straight forward cases according to SAC classification

Exclusion criteria

✕. Patients with signs of acute or chronic infection in the implant zone
✕. Patients with signs of parafunctional habits
✕. Patients with history of systemic diseases or recent radiotherapy to the head and neck or chemotherapy.
✕. Patients who had history or were currently under treatment with oral or intravenous bisphosphonate or statins other drugs that may alter bone metabolism
✕. Patients who are heavy smoker or presented with severe periodontitis.
✕. Pregnant patients.

What they're measuring

Implant Stability Quotient (ISQ)

Timeframe: Baseline, 8 weeks, and 16 weeks

Trial details

NCT IDNCT07194447

SponsorMaha Zuhair

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-06

View on ClinicalTrials.gov More Dental Implants , Osseointegration , Marginal Bone Loss , Implant Stability trials