Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis (NCT07194174) | Clinical Trial Compass
RecruitingNot Applicable
Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis
Denmark36 participantsStarted 2025-10-02
Plain-language summary
This study wishes to investigate the effects of strength exercise in patients with either HypoPP or HyperPP.
The investigators wishes to include participants already diagnosed with either HypoPP or HyperPP in af 24 week prospective study where the patients will be tested and asked to fill out questionnaires three times. These appointments will be schedueled at week 0, week 12 and week 24.
In the time period between week 12 and week 24, the patients will have a personalized strength exercise program, which they will have to follow these 3 months. The exercise will be supervised by one or more of the investigators.
We will also assess the muscle structure and function cross sectionally.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with genetic verified HypoPP or HyperPP
* Age minimum 18 years
* Able to walk a minimum of 10 meters independently with or without assistive devices and be able to stand from a chair without using hands
Exclusion Criteria:
* Other significant cause of muscle weakness
* Heart or lung disease which, in the investigator's opinion, makes participation in the study training inadvisable
Exclusion from muscle biopsy
* Anticoagulant treatment
* Impaired blood clotting due to disease
Exclusion from MRI scanning due to:
* Metal implants in the body that contraindicate MRI scanning or are positioned such that the scan quality is significantly affected
* Claustrophobia
* Pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Functional endurance test in the form of the Five Times Sit-to-Stand Test (5STS)
Timeframe: From intervention to end of intervention at 12 weeks