CompletedNot Applicable

Respiratory Function, Physical Activity and Fatigue in SLE

Turkey (Türkiye)50 participantsStarted 2025-09-05

Plain-language summary

Increasing awareness of possible pulmonary involvement in patients with systemic lupus erythematosus (SLE) will enable earlier diagnosis of the disease and minimize damage accumulation. According to our research, no study has been found that examines respiratory functions in detail in SLE patients and investigates their relationship with functional capacity, physical activity, and fatigue levels. Our primary aim is to compare respiratory functions, functional capacity, physical activity, and fatigue levels between patients with SLE and healthy controls. Our secondary aim is to investigate the relationship between respiratory functions with functional capacity, physical activity levels, and fatigue in SLE patients.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who have been followed with a diagnosis of systemic lupus erythematosus for at least 1 year * Able to ambulate independently * No cognitive or mental impairment * Willing to participate in the study Exclusion Criteria: * Presence of major musculoskeletal disease affecting the lower extremities * Presence of severe disease affecting the cardiovascular system * Being pregnant * Smoking * Having a diagnosis of restrictive/interstitial lung disease due to the underlying condition

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Forced Vital Capacity (FVC)

Timeframe: Time Frame: Baseline (day of enrollment) assessment

Forced Expiratory Volume (FEV1)

Timeframe: Baseline (day of enrollment) assessment

Tiffeneau Index (FEV1/FVC)

Timeframe: Baseline (day of enrollment) assessment

Peak Expiratory Flow (PEF)

Timeframe: Baseline (day of enrollment) assessment

Functional Capacity

Timeframe: Time Frame: Baseline (day of enrollment) assessment

Physical Activity Level

Timeframe: Baseline (day of enrollment) assessment

Trial details

NCT IDNCT07193745

SponsorMelis Usul

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-10-15

View on ClinicalTrials.gov More Systemic Lupus Erythematosus trials

Plain-language summary

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Forced Vital Capacity (FVC)

Timeframe: Time Frame: Baseline (day of enrollment) assessment

Forced Expiratory Volume (FEV1)

Timeframe: Baseline (day of enrollment) assessment

Tiffeneau Index (FEV1/FVC)

Timeframe: Baseline (day of enrollment) assessment

Peak Expiratory Flow (PEF)

Timeframe: Baseline (day of enrollment) assessment

Functional Capacity

Timeframe: Time Frame: Baseline (day of enrollment) assessment

Physical Activity Level

Timeframe: Baseline (day of enrollment) assessment