Effect of Fruit Elicitation With Melatonin on Human Health (NCT07192835) | Clinical Trial Compass
CompletedNot Applicable
Effect of Fruit Elicitation With Melatonin on Human Health
Spain22 participantsStarted 2025-03-01
Plain-language summary
The goal of this clinical trial is to learn if treating fruits with melatonin helps the body absorb and use healthy plant compounds. It will also learn how much melatonin from the fruits is taken up by the body. The main questions it aims to answer are:
* Does melatonin treatment of fruits raise the amount of healthy compounds the body absorbs?
* Does melatonin from treated fruits appear in urine after eating them?
Researchers will compare juice made from melatonin-treated fruits to juice made from untreated fruits to see if melatonin changes absorption.
Participants will:
* Follow a special low-plant-compound diet for 3 days before each test day
* Drink 300 grams of juice from treated or untreated fruit while fasting
* Provide urine samples before and after drinking the juice
* Return 15 days later to switch to the other juice type
* Repeat this process with lemon, blood orange, and cherry
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy adults aged 18-65 years
* Body mass index (BMI) between 18.5 and 24.9 kg/m²
* Non-smokers
* No chronic diseases (such as diabetes, cardiovascular disease, or cancer)
* Not taking regular medication
* Willing to follow a diet low in phenolic compounds and melatonin during the study periods
* Able and willing to provide urine samples according to study instructions
Exclusion Criteria:
* Presence of chronic diseases or metabolic disorders
* Use of medications that could affect metabolism or absorption of compounds
* Smoking or use of nicotine products
* Allergies or intolerance to citrus fruits or cherries
* Pregnancy or breastfeeding
* Inability or unwillingness to comply with study procedures or dietary restrictions
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Biodisponibility of phenolic compounds and melatonin from melatonin-treated fruits
Timeframe: 0-3.5, 3.5-12, and 12-24 hours post-consumption for each intervention period