Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women

Inclusion Criteria: * Women aged 60-75 years old, any ethnicity. * Participants with T- score between \< 1.0 and \> -2.5 measured by DXA scan within 6 months of the first day of the study. * Adequate cognitive function to be able to give informed consent. Exclusion Criteria: * Osteoporosis and fracture history * Participants with osteoporosis (defined by DXA scan \< 6 months old: low bone mass, T-score \< -2.5 or hip fracture or clinical compression fracture of the spine). * History of low energy fractures within last 6 months. Health conditions limiting exercise * Health conditions that could limit walking and weightbearing exercise (for instance recent surgery, mobility limitation) * Participants with impaired wound healing or history of a chronic open wound Bone metabolism disorders * Primary hyperparathyroidism. * Known vitamin D deficiency (\<25 nM) (re-test after substitution acceptable). * Known disorders affecting bone metabolism, e.g., uncontrolled thyrotoxicosis, severe renal impairment (eGFR \< 30) or impaired liver function (baseline phosphatase higher than twice upper limit (105 U/L)), active rheumatic diseases, celiac disease, severe chronic obstructive lung disease (COPD), hypopituitarism, or Cushing's disease. * Previous use of bone antiresorptive or bone anabolic drugs within the last 5 years. Medication use and health conditions * Use of anabolic steroids in the previous year. * Use of antiresorptive therapy in the previous year. * Know…