How do Patients With Amnesia Acquire New Knowledge? (NCT07191197) | Clinical Trial Compass
RecruitingNot Applicable
How do Patients With Amnesia Acquire New Knowledge?
France150 participantsStarted 2026-04-08
Plain-language summary
THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion Criteria:
* Patients aged between 18 and 70 years
* Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation
* Written agreement to participate in the study
* Intellectual capacities compatible with the cognitive tasks and signing of consent
* Affiliation to the French social security system
* For patients: bilateral brain lesion of the medial temporal lobe or the extended hippocampal system
Exclusion Criteria:
* Subjects under the age of 18 or over 70
* Contraindications for MRI (examples: wearers of a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, wearers of haemostatic clips for intracerebral aneurysms or carotid arteries, wearers of orthopedic implants, claustrophobic)
* Refusal to be informed of an anomaly detected during the MRI
What they're measuring
1
Performance on Fast-Mapping semantic learning task