CompletedNot Applicable

Diastolic Dysfunction 2025

Tunisia80 participantsStarted 2025-03-01

Plain-language summary

This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women. A total of 80 pregnant women in the third trimester were enrolled, including 40 with preeclampsia (mostly severe forms) and 40 healthy controls. All participants underwent standardized transthoracic echocardiography to assess left ventricular diastolic function according to the 2016 ASE/EACVI recommendations.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pregnant women aged 18-45 years * Third trimester of pregnancy * Group A: women diagnosed with preeclampsia according to international criteria (blood pressure ≥ 140/90 mmHg after 20 weeks with proteinuria or signs of severity) * Group B (controls): normotensive pregnant women without proteinuria or cardiovascular disease * Signed informed consent Exclusion Criteria: * Known pre-existing cardiovascular disease (structural heart disease, heart failure, chronic hypertension complicated) * Left ventricular ejection fraction \< 45% * Pre-gestational diabetes * Chronic kidney disease * Multiple pregnancy * Other severe comorbidities that could affect cardiac function independently of preeclampsia

What they're measuring

Prevalence of Left Ventricular Diastolic Dysfunction in Preeclamptic Women

Timeframe: At baseline, during third-trimester pregnancy hospital evaluation.

Trial details

NCT IDNCT07190846

SponsorUniversity Tunis El Manar

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-07-31

View on ClinicalTrials.gov More Preeclampsia trials