Efficacy of Propofol Combination With Either Ketamine, Dexmedetomidine or Midazolam for Sedation During Upper Gastrointestinal Endoscopic Procedures

Inclusion Criteria: * Both male and female patients aged between 18 and 65 years * Patients who are scheduled for elective upper gastrointestinal endoscopic procedures with sedation * Patients who are classified as ASA (American Society of Anesthesiologists) I and II Exclusion Criteria: * Patient's refusal to participate * Respiratory compromise as patients with respiratory failure or with active chest conditions, e.g., bronchial asthma or pneumonia * Cardiovascular compromise including heart failure and shocked patients * Severe uncontrolled hematemesis with shock or risk of aspiration. * Patients who are allergic or have any contraindications to any of the used drugs. * Patients who have a chronic neuropsychiatric disorder or are on a neuropsychiatric drug. * Patients on long-term sedative medication have a history of drug or alcohol abuse. * Pregnancy and lactation