Prilocaine for Sphenopalatine Ganglion Block in Endoscopic Hypophysectomy (NCT07188987) | Clinical Trial Compass
RecruitingNot Applicable
Prilocaine for Sphenopalatine Ganglion Block in Endoscopic Hypophysectomy
Egypt54 participantsStarted 2025-12-01
Plain-language summary
Patients undergoing endoscopic surgeries for pituitary adenoma excision suffer from wide swings in blood pressure that might increase bleeding and interfere with the surgical field.
Local anethetic infiltration and regional nerve blocks have been used to provide better analgesia, control blood pressure and improve surgical field.
Limited studies evaluated shenopalatine ganglion block in pituitary adenoma excision with promising outcomes. The proposed study will compare the efficacy of two local anesthetics, prilocaine and lidocaine, for spenopalatine ganglion block in patients undergoing endoscopic pituitary adenoma excision. Evaluating the control of the intraoperative blood pressure and analgesic sparing are the main objectives of the proposed study.
Who can participate
Age range
21 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with pituitary adenoma undergoing endoscopic hypophysectomy.
* ASA physical status I and II.
* Age above 21, below 45 years.
* Male or female
Exclusion Criteria:
* Any patient below 21 years or above 45 years.
* Patients suffering from any of the following conditions:
* Disturbed conscious level.
* Coagulation abnormalities.
* Poorly controlled blood pressure and/or heart rate.
* Increased intracranial tension.
* Liver and kidney disorders.
* Patients on anticoagulants and/or NSAIDS (non-steroidal anti- inflammatory drugs
* Patients addicted to drugs and/or alcohol.
* Patients with disturbed conscious level at the end of the surgery, GCS \>14
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
MAP
Timeframe: Mean arterial blood pressure in mmhg in the intraoperative period 5 minutes after nasal dissection
2
MAP
Timeframe: Mean arterial blood pressure in mmhg after 5 minutes of nasal dissection