CompletedNot Applicable

Respiratory Safety of Oliceridine During Sedated Gastrointestinal Endoscopy

China508 participantsStarted 2025-09-22

Plain-language summary

This study is a prospective, single-center, double-blind, randomized controlled trial designed to evaluate the effect of oliceridine versus sufentanil on the incidence of hypoxemia in adult patients undergoing gastrointestinal endoscopy under deep sedation. The trial will compare the rates of hypoxemia (defined as SpO₂ ≤92%) between the two analgesic regimens when combined with propofol. The primary aim is to determine whether oliceridine can reduce the incidence of hypoxemia compared to sufentanil during endoscopic procedures.

Who can participate

Age range18 Years – 99 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female patients aged ≥ 18 years. * Scheduled to undergo elective gastrointestinal endoscopy (gastroscopy or colonoscopy). * American Society of Anesthesiologists (ASA) physical status I-III. * No history of severe cardiopulmonary dysfunction or other major systemic disease. Exclusion Criteria: * Dementia or any cognitive impairment precluding provision of informed consent. * Known contraindication to oliceridine. * Chronic (long-term) opioid use. * Any other medical or logistic condition that, in the investigator's judgment, makes the participant unsuitable for the study (specify reason).

What they're measuring

Incidence of Hypoxemia (SpO₂ ≤92%) During Sedation for Gastrointestinal Endoscopy

Timeframe: From the start of sedation to the end of the gastrointestinal endoscopic procedure (approximately 1-60 minutes)

Trial details

NCT IDNCT07187765

SponsorShiyou Wei

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-30

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