Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Are… (NCT07185100) | Clinical Trial Compass
RecruitingNot Applicable
Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Germany600 participantsStarted 2025-09-13
Plain-language summary
Heart failure (HF) in patients at risk is often overlooked, and when detected, there is a lack of early and effective preventive interventions. The WE-CARE-HF-CMR study, conducted in large cities/metropol areas in Germany ( \> 1.000.000 inhabitants), aims to close this gap by evaluating the feasibility of a mobile, telemedicinemonitored HF-screening approach combining cardiac magnetic resonance imaging (CMR), quality of life assessment and laboratory tests as key elements in asymptomatic patients at risk. WE-CARE-HF-CMR will provide a proposal for a comprehensive, contemporary screening approach for patients at risk to develop HF tailored to the needs of the target population. This will provide important new information on the prevalence of asymptomatic HF in at-risk patients in urban versus rural areas.
The results of the study will be compared with the results from the "HERZCheck'' trial, which provides data from approximately 4,500 participants in rural areas in Germany and has already been completed (NCT05122793).
Who can participate
Age range
40 Years – 69 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Asymptomatic subjects with:
* chronic diabetes mellitus (known/diagnosed and/or antidiabetic medication and/or elevated HbA1C) and/or
* renal impairment (known/diagnosed CKD and/or in laboratory CKD III° or higher) and/or
* Hypertension (known/diagnosed and/or antihypertensive medication/treatment) and/or
* Hypercholesterolaemia (known/diagnosed and/or antilipid medication/treatment) and/or
* Obesity (known/diagnosed and/or BMI \> 30 (kg/m²)) and/or
* Smoker (known/diagnosed and/or current/previous and/or medication/treatment)
* Age 40-69 years
* female or male or diverse sex
* Ability to provide informed consent
* Provision of Informed Consent
Exclusion Criteria:
* Inability to provide written informed consent
* Diagnosed heart failure or previously detected reduced ejection fraction
* General MRI exclusion criteria (pacemaker, defibrillator, intracranial aneurysm clips, metallic foreign bodies in the eyes)
* Any MRI exclusion criteria not listed here, as determined by the MRI laboratory performing the procedure
* Haemodynamically unstable participants (heart rate \< 45/min, systolic blood pressure \< 90 mmHg)
* Claustrophobia
* Sensorineural hearing loss of 30 dB or more and tinnitus
* Acute mental disorders requiring therapy
* In the presence of pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Prevalence of asymptomatic pre-heart failure (stage B) in an urban population