RecruitingNot Applicable

Intra-arterial Thrombolysis for Acute Ischemic Stroke With Medium Vessel Occlusion

China282 participantsStarted 2026-01-06

Plain-language summary

Acute ischemic stroke (AIS) due to medium vessel occlusion (MeVO) or severe stenosis poses a significant clinical challenge. Recent large randomized controlled trials, DISTAL and ESCAPE-MeVO, demonstrated no significant benefit of endovascular therapy in patients with MeVO. Although intra-arterial thrombolysis has shown promise in clinical experience, robust evidence supporting its efficacy in MeVO or severe stenosis-related AIS is still absent. To fill this gap, the RESCUE MeVO trial has been designed as a multicenter, prospective, randomized, open-label, blinded end-point (PROBE) study to evaluate the efficacy and safety of intra-arterial thrombolysis in patients with AIS caused by MeVO or severe stenosis.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Acute ischemic stroke within 24 hours of symptom onset or last known well, including stroke with known onset, wake-up stroke and stroke with unknown onset, with no obvious hypodensity on CT and good collateral circulation on CTA;
✓. Acute ischemic stroke within 24-72 hours of onset, meeting at least one of the following imaging criteria: a.CT or MR perfusion imaging demonstrating target mismatch, defined as an ischemic core volume \<30 mL, a mismatch ratio ≥1.2, and a mismatch volume ≥10 mL.; b.MRI demonstrating DWI-FLAIR mismatch, defined as the presence of acute ischemic lesions on diffusion-weighted imaging (DWI) with no corresponding hyperintense signal on FLAIR, or with FLAIR hyperintense lesions occupying less than one-third of the DWI lesion volume.

What they're measuring

Excellent outcome

Timeframe: Time Frame: 90 ± 7 days

Trial details

NCT IDNCT07185022

SponsorThe Second Hospital of Anhui Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-02-01

Contact for this trial

Qi Li, professor

+8618623511778 qili_md@126.com

View on ClinicalTrials.gov More Stroke trials