this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery. The main questions it aims to answer is: * Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions? * Can these biomarkers be used as potential tools for early identification in vulnarable populations?
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Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function?
Timeframe: preoperatively and four weeks postoperatively