CompletedPhase 4

Healing of Intrabony Defects Following Treatment With PRF or EMD

Hungary28 participantsStarted 2021-09-01

Plain-language summary

Objective: To evaluate clinically the long-term results following treatment of deep intrabony defects with either platelet-rich fibrin gel (PRF) or an enamel matrix derivative (EMD). Methods: Twenty six patients diagnosed with advanced chronic periodontitis, and each of whom displaying one deep intrabony defect were randomly treated with open flap debridement and with either PRF (test) or EMD (Emdogain, Straumann, Basel, Switzerland) (control). The clinical outcomes were evaluated at baseline, at six months and three years after treatment. The primary outcome variable was the clinical attachment level (CAL).

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. No systemic conditions affecting treatment outcomes
✓. Good oral hygiene \[plaque index (PI) \<1; Löe 1967\]
✓. Compliance with the maintenance program
✓. Presence of at least one intra-bony defect with a probing depth (PD) of ≥6 mm and an intra-bony component of ≥3 mm confirmed by radiographs.

What they're measuring

Probing pocket depth (PPD)

Timeframe: preop and after 6 months

Trial details

NCT IDNCT07183631

SponsorSemmelweis University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-01

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