Novel Skin Barrier Product Versus Petrolatum for Skin Barrier Dysfunction (NCT07183423) | Clinical Trial Compass
RecruitingNot Applicable
Novel Skin Barrier Product Versus Petrolatum for Skin Barrier Dysfunction
Philippines26 participantsStarted 2025-08-31
Plain-language summary
The goal of this clinical trial is to learn if a novel barrier topical product works to treat barrier dysfunction in adults. It will also learn about the safety of the novel barrier topical product. The main questions it aims to answer are:
Does the novel barrier topical product improve skin hydration, skin sebum, redness, and pigmentation? Does it improve subjective dryness and itch? Researchers will compare the novel barrier topical product to petrolatum (a gold standard occlusive barrier repair agent) to see how they are comparable in treating skin barrier dysfunction.
Participants will:
Apply the novel barrier topical product or petrolatum twice a day for 28 days Visit the clinic once a week for checkups and tests Keep a diary of their application of the assigned product
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Clinical diagnosis of mild skin barrier dysfunction, including:
* Mild to moderate atopic dermatitis, defined as SCORAD ≤ 50, and/or not currently requiring topical corticosteroids or immunomodulators.
* Mild to moderate chronic plaque psoriasis, defined as total body surface area (BSA) involved: ≤3% to 10%.
* Contact dermatitis
* Seasonal xerosis or clinically evident skin dryness
* Symmetrical or bilateral test areas available (volar forearm)
* Willing and able to provide informed consent and adhere to study procedures
Exclusion Criteria:
* Failure to meet any of the above inclusion criteria
* Severe atopic dermatitis or psoriasis requiring systemic or high-potency topical treatment
* Use of corticosteroids, calcineurin inhibitors, biologics, or phototherapy within 2 weeks
* Open wounds or evidence of secondary infection at test sites
* Pregnant or breastfeeding women
* Multiple nevi, tattoos, dense body hair in the test areas
* Debilitated or immunocompromised subjects
* Known or suspected hypersensitivity to the interventional product (or its ingredients) or petrolatum
* Refusal or failure to comply with the schedule of visits at the test site.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.