RecruitingNot Applicable

Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)

United States25 participantsStarted 2025-08-11

Plain-language summary

The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life. Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.

Who can participate

Age range18 Years – 85 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-85 * ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80) * Able to use the wearable and participate in a remote exercise program * Able to participate in intermittent high-intensity training. * Able to perform cardiopulmonary exercise testing (CPET) * Able to provide Health-related quality of life questionnaire (HRQOL) * Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English Exclusion Criteria: * Systolic heart failure (LVEF \<50% or NYHA class III symptoms) * Prior myocardial infarction, coronary revascularization * Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment * Pregnancy (due to unknown effects on CPET exercise markers) * Inability to provide informed consent * Life expectancy \<1 year * Prisoners * Cognitively impaired * Non-English speaking

What they're measuring

Examine cardiorespiratory fitness (change in VO2max in mL/kg/min) with cardiopulmonary exercise testing (CPET) Phenotype.

Timeframe: 4 weeks

Trial details

NCT IDNCT07182955

SponsorUniversity of Virginia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-30

Contact for this trial

Rahel Askari

434-243-7195 rahel.askari@uvahealth.org