Polyphenol Metabolism and Personalized Nutrition in Menopause (PolyPause).

Inclusion Criteria: * Women aged 45 to 57 years. * Diagnosed menopause (defined as 12 consecutive months without menstruation). * Presenting at least one climacteric symptom (hot flashes and/or sweating episodes and/or low mood and/or irritability and/or decreased libido and/or insomnia and/or joint/muscle pain). * Body Mass Index (BMI) ≥ 18 kg/m². * Adequate cultural level and ability to understand the clinical study. * Willing to voluntarily participate in the study and provide written informed consent. Exclusion Criteria: * Presence of severe, chronic-degenerative, or psychiatric conditions, or any contraindication to the use of nutritional supplements. * History of major gastrointestinal surgery. * Swallowing difficulties (e.g., inability to ingest capsules). * BMI \< 18 kg/m² or \> 30 kg/m². * Currently following a weight-loss regimen. * Known or suspected allergy or intolerance to red clover extract, resveratrol (grape, wine), soy, or pomegranate. * Use of chronic preventive medication for cholesterol, glucose, blood pressure, etc. (e.g., statins, metformin, beta-blockers). * Use of antibiotics within one month prior to study initiation. * Undergoing hormone replacement therapy. * Alcohol consumption exceeding 1 beer or 1 glass of wine per day. * Regular use of dietary supplements (e.g., probiotics, isoflavones, resveratrol, others). * Following a vegetarian diet. * Current smoker or having smoked at any time during the past year. * Individuals unwilling to comply wi…