WithdrawnPhase 4

Ketamine in Central Sensitization

Stopped: Study never opened

United States0Started 2026-02-01

Plain-language summary

The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA. Patients will be randomized to either receive standard anesthesia with OR without ketamine. The surgical procedure will be the same regardless of which group patients are randomized to. After surgery, patients will be asked to rate their pain in the post-operative observation unit and at their two-week post-operative visit. No additional visits are required for participation in this study. The investigators estimate the surveys will take approximately 10 minutes to complete.

Who can participate

Age range18 Years – 89 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age range 18-89 * ASA classification I-III * outpatient elective laparoscopy for endometriosis Exclusion Criteria: * known allergy or contraindication to ketamine * History of substance use disorder, including alcohol or marijuana use, both current and remote * History of severe psychiatric illness, including schizoaffective disorder, bipolar disorder, psychosis, or decompensated psychiatric condition , excluding anxiety and depression * Current Intraoperative complications

What they're measuring

change in pain as measured by visual analog scale

Timeframe: approximately post-operative day 0 and 14

Trial details

NCT IDNCT07182032

SponsorUniversity Hospitals Cleveland Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06-30

View on ClinicalTrials.gov More Endometriosis trials