RecruitingNot Applicable

Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients

Thailand46 participantsStarted 2025-10-10

Plain-language summary

This single-center, crossover randomized controlled trial (HyPIR-ICU) investigates whether a Hypotension Prediction Index (HPI)-guided management strategy can reduce intradialytic hypotension (IDH) during prolonged intermittent renal replacement therapy (PIRRT) in critically ill patients. All participants must have an indwelling arterial catheter for continuous hemodynamic monitoring.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults \>18 years old * Diagnosed with acute kidney injury (AKI) or end-stage kidney disease (ESKD) * Admitted to medical ICU * Scheduled for PIRRT * Have an indwelling arterial catheter Exclusion Criteria: * Severe right heart dysfunction, significant valvular disease, arrhythmias, mechanical circulatory support, absence of arterial access, no UF prescription, palliative care, or expected ICU stay \<72 hours.

What they're measuring

- Time-weighted average mean arterial pressure <65 mmHg (TWA-MAP<65 mmHg)

Timeframe: Day 1 and Day 3

Trial details

NCT IDNCT07179705

SponsorChulalongkorn University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

Contact for this trial

Nattapakorn Mai-on

66970051116 nattapakorn.m@gmail.com

View on ClinicalTrials.gov More Intradialytic Hypotension trials