By InvitationNot Applicable

Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients

China160 participantsStarted 2025-10-20

Plain-language summary

When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by centrifugation, and the serum sample is frozen for final centralized biomarker detection), and measure the antral movement index under ultrasound (300ml of warm water is injected into the stomach before measurement, and then the antral movement is observed for 6 minutes) Then, monitor whether the patient has developed feeding intolerance within 7 days of the ICU

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 years * Presence of one or more organ system failures within 24 hours of ICU admission (SOFA score ≥2) * Expected ICU stay \>48 hours * Inability to take oral nutrition * No contraindications to enteral nutrition (EN) Exclusion Criteria: * Patients who have already received enteral nutrition prior to gastric antral motility measurement or biomarker collection * Receiving palliative care with expected death within 48 hours * Pregnancy * Participation in another clinical trial

What they're measuring

The subject developed feeding intolerance within 7 days of the ICU

Timeframe: The first to seventh days in the ICU

Pragmatic Definition of Enteral Feeding Intolerance (EFI) - Sensitivity Analysis of the Primary Outcome

Timeframe: From enrollment (ICU admission) through day 7 of enteral nutrition

Trial details

NCT IDNCT07178626

SponsorThe First Hospital of Jilin University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-07-31