CompletedNot Applicable

The Effects of Nextida-GC and Whey Protein on Postprandial Glycemic and Insulinemic Responses When Given 30min Before, 10min Before or With a Standardized Breakfast Test-meal in Healthy Adults With and Without Prediabetes

Canada32 participantsStarted 2025-09-08

Plain-language summary

The goals of this clinical trial are to learn if Nextida-GC (a peptide derived from collagen) will reduce postprandial glucose responses when taken 30 minutes before, 10 minutes before or with the first bite of a breakfast test-meal consisting or bread, margarine and jam with a drink coffee, tea or water (each subject will choose a drink and have the same drink each time). The main questions it aims to answer are: Does Nextida-GC reduce glucose responses more than whey protein? What are the effects of Nextida-GC and whey protein on plasma glucose and serum insulin responses when given 30 minutes before eating, 10 minutes before eating, or with the breakfast test meal? Overall, is it better to take Nextida-GC 30 minutes before eating, 10 minutes before eating, or with the breakfast test meal? Participants will: Come to the research center (INQUIS Clinical Research, Toronto, Ontario, Canada) on 8 separate occasions (with bewteen 3 and 14 days between visits) after an overnight fast of at least 10 hours. Each participant will undergo all 8 treatments (one treatment per visit): Block 1 * 10 grams Nextida-GC in water 30 minutes before eating the test-meal * 10 grams Nextida-GC in water 10 minutes before eating the test-meal * water 30min before eating and 10g Nextida-GC in water with the test-meal * water 30min before eating, and water with the test-meal Block 2 * 10 grams whey protein in water 30 minutes before eating the test-meal * 10 grams whey protein in water 10 minutes before eating the test-meal * water 30min before eating and 10g whey protein in water with the test-meal * water 30min before eating, and water with the test-meal The order of the blocks will be randomized and the order of the treatments within the blocks will be randomized. On each occasions finger-stick blood samples for measuring glucose and insulin will be obtained 30, 10 and 0 minutes before starting to eat the test-meal and 15, 30, 45, 60, 90, 120 and 180 minutes after the first bite of the test-meal. The main outcome of the study is the area under the curve of plasma glucose from 0 to 180 minutes.

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Non-pregnant, non-lactating. * BMI 18.5 to 35.0 kg/m² inclusive. * n=20 with prediabetes: fasting glucose 5.6-6.9 mmol/L and/or HbA1c 5.7-6.4%. * n=12 without prediabetes: fasting glucose \<5.6 mmol/L and HbA1c \<5.7%. * Systolic blood pressure \<160mmHg and diastolic blood pressure \<100mmHg. * Willing to abstain from unusual strenuous exercise and consuming alcoholic drinks for 24 hours before study days. * Willing to refrain from smoking tobacco or using marijuana in any form (including but not limited to smoking, vaping, edibles, tinctures, or other ingestible or inhalable preparations) for 12h before and during study visits. * Willing to consume study products that contain animal derived ingredients * Understand the study procedures and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator. * Eligible to receive income in Canada and covered by a health insurance plan such as OHIP. Exclusion Criteria: * Failure to meet any one of the inclusion criteria. * Major trauma or surgical event within 3 months of screening. * Use of supplements containing collagen and/or high dose of chromium (\>500mcg). * The presence of any laboratory result, health condition, illness or drug use that increases risk to the subject or to others or may affect the results, as judged by the Qualified Investigator. * Unwillingness or inability to comply with experimental pro…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Glucose iAUC 0-180

Timeframe: 0 min to 180 minutes

Trial details

NCT IDNCT07174323

SponsorINQUIS Clinical Research

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2025-11-24

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