Not Yet RecruitingNot Applicable

The TiMeD-T1D Project

Denmark10 participantsStarted 2025-11-01

Plain-language summary

The aim of the proposed study is to investigate the metabolic consequences of varying the timing of meal insulin boluses and skipping boluses altogether in individuals with type 1 diabetes. The investigator hypothesize that delaying or skipping meal insulin boluses leads to greater ectopic fat storage due to a delayed stimulation of lipoprotein activity and delayed suppression of lipolysis and VLDL-TG secretion.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Type 1 diabetes duration \> 3 years or c-peptide negative * Written and informed consent Exclusion Criteria: * Medicine with an impact on blood glucose or blood pressure * Affected screening blood sample as evaluated by the clinical responsible investigator. * Alcohol or substance abuse * BMI \> 35 kg/m2 or \< 18.5 kg/m2 * Participation in other clinical trials involving ionized radiation within the last 6 months * Lactose intolerance * Doesn't speak and understand Danish. * Severe claustrophobia. * Commitment to special diets

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Difference in meal fat storage in visceral adipose tissue

Timeframe: 18F-FTHA PET scan 300 minutes after consumption of the liquid mixed meal

Trial details

NCT IDNCT07172672

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-02-01

Contact for this trial

Jens H. Voigt, MD

0026395294 Jens.voigt@clin.au.dk

View on ClinicalTrials.gov More Postprandial Lipid Metabolism trials