Not Yet RecruitingNot Applicable

The TiMeD-T1D Project

Denmark10 participantsStarted 2025-11-01

Plain-language summary

The aim of the proposed study is to investigate the metabolic consequences of varying the timing of meal insulin boluses and skipping boluses altogether in individuals with type 1 diabetes. The investigator hypothesize that delaying or skipping meal insulin boluses leads to greater ectopic fat storage due to a delayed stimulation of lipoprotein activity and delayed suppression of lipolysis and VLDL-TG secretion.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Type 1 diabetes duration \> 3 years or c-peptide negative * Written and informed consent Exclusion Criteria: * Medicine with an impact on blood glucose or blood pressure * Affected screening blood sample as evaluated by the clinical responsible investigator. * Alcohol or substance abuse * BMI \> 35 kg/m2 or \< 18.5 kg/m2 * Participation in other clinical trials involving ionized radiation within the last 6 months * Lactose intolerance * Doesn't speak and understand Danish. * Severe claustrophobia. * Commitment to special diets

What they're measuring

Difference in meal fat storage in visceral adipose tissue

Timeframe: 18F-FTHA PET scan 300 minutes after consumption of the liquid mixed meal

Trial details

NCT IDNCT07172672

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-02-01

Contact for this trial

Jens H. Voigt, MD

0026395294 Jens.voigt@clin.au.dk

View on ClinicalTrials.gov More Postprandial Lipid Metabolism trials