A Multicenter Study to Optimize Microembolic Signal Classification Based on Double--Blind Multiparametric Assessment by Human Experts Using an Universal Graphical Interface [MESOMEGA]

Inclusion Criteria: MES of presumed solid form or non-MES high intensity transient signals Obtained from on a human subject with age equal to or more than 18years old Obtained from proximal middle cerebral artery (M1 segment) Clip with 20 seconds duration with clearly event of interest marked using TCDPlayer With an overall background spectrum of reasonable quality to be analyzed Exclusion Criteria: MES in gaseous form Use of ultrasound contrast agent or agitated saline in the previous 24 hours Obtained from patients with mechanical valve Obtained from patient during any cardiac surgery or endovascular procedure1 Obtained from patient with recent severe trauma Clips with multiples inseparable MES (e.g. curtain)