This Study Aims to Clinically Assess and Radiographically Measure the Formed Dentin Bridge Over t… (NCT07171775) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
This Study Aims to Clinically Assess and Radiographically Measure the Formed Dentin Bridge Over the Pulp, Utilizing Three-dimensional Imaging Following the Application of a Bioactive Restorative System Versus a Conventional Restorative System After Selective Caries Removal to Soft Dentin Over 2
66 participantsStarted 2026-06-01
Plain-language summary
This clinical trial aims to evaluate dentin bridge formation over the pulp following selective caries removal in permanent teeth with deep carious lesions (ICDAS scores 5-6). A total of 66 patients will be enrolled and randomly allocated to receive either a bioactive restorative system (bioactive universal adhesive combined with a bioactive bulk-fill resin composite) or a conventional non-bioactive restorative system. Clinical assessments, including pulp sensibility testing and patient-reported pain evaluation, together with three-dimensional radiographic analysis using cone beam computed tomography, will be conducted to assess the thickness and quality of reparative dentin bridge formation. Outcomes will be evaluated at baseline and during follow-up periods extending up to 24 months to compare the effectiveness of both restorative approaches in preserving pulp sensibility and promoting dentin-pulp complex repair.
Who can participate
Age range18 Years – 40 Years
SexALL
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Inclusion criteria
✓. Adult patients (age: 18-40 years) of both genders.
✓. Good oral hygiene.
✓. Willing to sign the informed consent.
✓. Cooperative patients who accept the follow-up period.
✓. Posterior permanent caries (ICDAS 5-6).
✓. Radiographically, caries is extending 50% of dentine with a radiopaque layer between the carious lesion and the pulp chamber.
✓. Sensitive teeth according to the cold pulp test.
✓. Negative response in percussion test.
Exclusion criteria
✕. Allergy to any of the restorative materials.
✕. Patients undergoing orthodontic treatment with fixed appliances.