Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Thera… (NCT07169461) | Clinical Trial Compass
By InvitationNot Applicable
Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Therapies in Demodex Blepharitis Using Artificial Intelligent Program (Ai-Demodex)
Thailand88 participantsStarted 2025-01-16
Plain-language summary
Primary Objective:
To evaluate the efficacy of LLLT, IPL, and IPL + LLLT in re ducing demodex count in patients with Demodex Blepharitis.
Secondary Objectives:
To evaluate the efficacy of LLLT, IPL, and IPL + LLLT in improving ocular surface parameters in Demodex Blepharitis.
Sample Size:
88 participant ( 22 participants per group x 4 groups)
Study Design:
2x2 Factorial randomized trial.
Methodology:
The study is composed of 4 groups including 1) control 2) Blue light LLT alone 3) IPL alon e, 4) Blue light LLLT with IPL , and .
Both LLLT and IPL will treat weekly for 4 sessions All participants will be instructed to perform warm compression and lid scrub. The outcomes include demodex count, meibum grading and ocular surface parameter were evaluated at 1 and 3 months post treatment.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. All patients who received a definite diagnosis of demodex blepharitis based on cylindrical dandruff at the base of the lashes and the presence of at least one alive demodex mites on eyelid margin by microscopy
✓. Age \>18 years.
✓. Patients who can understand and follow the study instructions and can adhere to the scheduled follow-up plan.
Exclusion criteria
✕. Patients who received previous treatment IPL or LLLT
✕. Poor compliance with eyelid scrubbing using tea tree oil (TTO)
✕. Dead demodex mite on lash.
✕. Contraindication of IPL: Skin Fitzpatrick scale V/VI, patients with pigmented lesions on the treatment area (Eyelid, Cheek).