Transfusion Exchanges and Cognition in Sickle Cell Disease (NCT07168447) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Transfusion Exchanges and Cognition in Sickle Cell Disease
France85 participantsStarted 2025-12-03
Plain-language summary
DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0). Information processing speed is assessed at three time points during the transfusion cycle using the Symbol Digit Modalities Test (SDMT) and additional validated neuropsychological measures. This minimal-risk, fully remote study aims to identify processing speed as a reproducible marker for clinical monitoring and future therapeutic trials.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults (≥18 years) with severe sickle cell disease (SS or Sβ0).
* Enrolled in a regular monthly transfusion exchange program.
* Not institutionalized.
* No known dementia.
* No severe aphasia.
* Affiliated with or beneficiary of a social security system.
Exclusion criteria:
* Insufficient mastery of spoken French.
* Severe comorbidities preventing short-term follow-up.
* Known psychiatric disorders.
* Participation in another clinical study with ongoing exclusion periods.
* Lack of adequate computer equipment (minimum 11-inch screen and internet connection).
* Vulnerable patients under legal protection (guardianship or curatorship).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Information Processing Speed
Timeframe: 48 hours before the transfusion exchange
2
Information Processing Speed
Timeframe: 7 to 9 days after the transfusion exchange
3
Information Processing Speed
Timeframe: within 48 hours before the next scheduled transfusion exchange