Transfusion Exchanges and Cognition in Sickle Cell Disease

Inclusion Criteria: * Adults (≥18 years) with severe sickle cell disease (SS or Sβ0). * Enrolled in a regular monthly transfusion exchange program. * Not institutionalized. * No known dementia. * No severe aphasia. * Affiliated with or beneficiary of a social security system. Exclusion criteria: * Insufficient mastery of spoken French. * Severe comorbidities preventing short-term follow-up. * Known psychiatric disorders. * Participation in another clinical study with ongoing exclusion periods. * Lack of adequate computer equipment (minimum 11-inch screen and internet connection). * Vulnerable patients under legal protection (guardianship or curatorship).