LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non… (NCT07168421) | Clinical Trial Compass
RecruitingPhase 4
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Switzerland114 participantsStarted 2026-04-24
Plain-language summary
Limiting perioperative tachycardia (aiming for a heart rate \<90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing major surgery might lower the incidence of perioperative myocardial injury. Feasibility of the intervention needs to be proven prior to conduction of a larger trial.
Who can participate
Age range45 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients undergoing elective non-cardiac surgery defined as intermediate or high-risk by the 2022 european society of cardiology (ESC) guidelines
* surgery performed under general anesthesia;
* expected length of hospital stay ≥ 24 hours;
* age ≥ 45 years;
* at least two of the following risk factors:
* age ≥ 75 years
* arterial hypertension;
* ischemic heart disease (history of myocardial infarction or positive exercise test, current complaint of chest pain considered to be secondary to myocardial ischemia, use of nitrates, pathological Q waves, prior coronary revascularization);
* history of congestive heart failure;
* history of cerebrovascular disease;
* peripheral artery disease;
* diabetes mellitus;
* GFR ≤ 59 ml/min pro 1.73 m2;
* pre-operative NTproBNP \> 200 pg/ml;
* excessive sympathetic outflow as proven by exercise testing:
* impaired heart rate recovery (≤ 12 bpm within 1 minute after cessation of exercise); OR
* exaggerated heart rate response (≥ 12 bpm after 3 minutes of unloaded pedalling);
Exclusion Criteria:
* unable to consent or follow study procedures;
* absolute contraindications for exercise testing;
* pregnancy or intention to become pregnant;
* active cardiac conditions (such as unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease);
* urgent / emergency surgery;
* already on β-blocker (within the last 30 days prior to recruitment);
* contraindication…
What they're measuring
1
Time perioperative heart rate in target range
Timeframe: From induction of anaesthesia until discharge from postanaesthetic care unit [percent of time heart rate within target range (<90 beats per minute)]