LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non… (NCT07168421) | Clinical Trial Compass
RecruitingPhase 4
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Switzerland114 participantsStarted 2026-04-24
Plain-language summary
Limiting perioperative tachycardia (aiming for a heart rate \<90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing major surgery might lower the incidence of perioperative myocardial injury. Feasibility of the intervention needs to be proven prior to conduction of a larger trial.
Who can participate
Age range
45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients undergoing elective non-cardiac surgery defined as intermediate or high-risk by the 2022 european society of cardiology (ESC) guidelines
* surgery performed under general anesthesia;
* expected length of hospital stay ≥ 24 hours;
* age ≥ 45 years;
* at least two of the following risk factors:
* age ≥ 75 years
* arterial hypertension;
* ischemic heart disease (history of myocardial infarction or positive exercise test, current complaint of chest pain considered to be secondary to myocardial ischemia, use of nitrates, pathological Q waves, prior coronary revascularization);
* history of congestive heart failure;
* history of cerebrovascular disease;
* peripheral artery disease;
* diabetes mellitus;
* GFR ≤ 59 ml/min pro 1.73 m2;
* pre-operative NTproBNP \> 200 pg/ml;
* excessive sympathetic outflow as proven by exercise testing:
* impaired heart rate recovery (≤ 12 bpm within 1 minute after cessation of exercise); OR
* exaggerated heart rate response (≥ 12 bpm after 3 minutes of unloaded pedalling);
Exclusion Criteria:
* unable to consent or follow study procedures;
* absolute contraindications for exercise testing;
* pregnancy or intention to become pregnant;
* active cardiac conditions (such as unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease);
* urgent / emergency surgery;
* already on β-blocker (within the last 30 days prior to recruitment);
* contraindication…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing landiolol to keep heart rate in a target range during surgery — how would my doctor know if I'm actually at high enough cardiovascular risk to make that kind of heart rate control important for my specific operation?
2Since this is a Phase 4 trial, landiolol has already been approved and used before — can my doctor explain what is already known about its safety, and what new questions this study is specifically trying to answer that aren't already answered?
3The trial is focused on preventing myocardial injury after non-cardiac surgery — how would my care team monitor me for that kind of heart injury during and after my procedure, whether or not I joined this trial?
4Given that beta blockers like landiolol can lower heart rate and blood pressure, what would my doctor watch for in terms of side effects during surgery, and how does that risk compare to the risk of not controlling my heart rate at all?
5Are there standard approaches my surgical or anesthesia team already uses to protect my heart during major surgery, and how does participating in this trial compare to just receiving that usual care?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time perioperative heart rate in target range
Timeframe: From induction of anaesthesia until discharge from postanaesthetic care unit [percent of time heart rate within target range (<90 beats per minute)]