A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Ki… (NCT07168356) | Clinical Trial Compass
RecruitingPhase 1
A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease
United States32 participantsStarted 2025-09-16
Plain-language summary
This is a 2-part study where all participants will receive bepirovirsen. The study will measure how much bepirovirsen from a single dose gets into the blood, and how long it stays in the blood. The purpose of the study is to understand if blood levels of bepirovirsen are different in adults with kidney disease compared to healthy adults who do not have kidney disease.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion Criteria:
* Age 18 to 80 years, inclusive
* Body weight greater than or equal to 50 kilograms (kg) and body mass index (BMI) within the range 19 to 40 kilograms per square meter (kg/m\^2).
* Males and females may participate. Female participants must not be pregnant or breastfeeding, and must be of non-childbearing potential, or agree to use a highly effective method of contraception.
* Capable of giving signed informed consent Additional inclusion criteria for renal impairment groups (Group 1 and Group 2)
* Severe renal impairment \[estimated glomerular filtration rate (eGFR) adjusted for actual body surface area (BSA) less than 30 milliliters per minute (ml/min); Group 1\] or moderate renal impairment \[eGFR adjusted for actual BSA between 30 and 59 ml/min; Group 2\], from any cause other than vasculitis or glomerulonephritis Additional inclusion criteria for healthy control participants with normal renal function (Group 3)
* Healthy, based on medical evaluation including medical history, physical examination, laboratory tests, and electrocardiogram (ECG).
* Normal renal function (eGFR adjusted for actual BSA greater than or equal to 90 ml/min)
Exclusion Criteria:
* Any medical condition that could affect the absorption, metabolism, or elimination of drugs, increase the risk of taking part in the study, or interfere with interpretation of the study data.
* History of vasculitis or any type of glomerulonephritis
* Use of creatine-containing supplements within 30…
What they're measuring
1
Plasma Area Under the Concentration Time Curve From Time Zero (Pre-Dose) Extrapolated to Infinite Time [AUC(0-∞)] of Bepirovirsen
Timeframe: Up to Day 50
2
Maximum Observed Concentration (Cmax) of Bepirovirsen