The Impact of Whey Protein on Frailty in Older Adults Classified as Pre-frail (NCT07167277) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
The Impact of Whey Protein on Frailty in Older Adults Classified as Pre-frail
United States20 participantsStarted 2025-12-05
Plain-language summary
This pilot study aims to determine the impact of whey protein supplementation on brain antioxidant levels and to assess the effects of whey protein supplementation on physical function, body composition, and cognition in pre-frail older adults.
Who can participate
Age range
65 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Pre-frail according to Fried's phenotype
* Age 65 to 85
* Speak English as primary language and able to read and write in English
* Stable medication for ≥ 30 days
* Not already taking whey protein over the past 30 days
Exclusion Criteria:
* Acute or chronic kidney disease
* Recent major health concerns
* Insulin-requiring diabetes
* Cancer requiring chemotherapy or radiation within the past 5 years
* Cardiac event (i.e., MI, etc.) in the past year
* Dementia or neurodegenerative disease
* Clinical trial or investigational drug or therapy participation within 30 days of the screening visit or during enrollment in the current study
* MRI contraindications (pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia)
* Dairy Allergy or excluding dairy from diet for other reasons
* Weight \> 350 lbs.
* The presence of major psychiatric disorders within the past 3 years including depression, anxiety, and alcohol (over 3 drinks/day or a total of 18 drinks/week) or drug abuse.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in brain glutathione (GSH) levels measured using MRI scans.